Pancreatin insufficiency, also known as pancreatic insufficiency or exocrine pancreatic insufficiency, is a medical condition that occurs when the pancreas does not produce enough digestive enzymes to properly break down and absorb nutrients from food. This can be caused by a variety of conditions that affect the pancreas, including c


Symptoms 
  • Steatorrhea : Excessive fat in the stool, which can make the stool appear greasy and difficult to flush.
  • Abdominal pain and bloating
  • Weight loss
  • Nutrient deficiencies: Malabsorption of nutrients such as vitamins A, D, E, and K can lead to deficiencies
  • Diarrhoea
  • Flatulence
Causes 
  • Chronic pancreatitis
  • Cystic fibrosis
  • Pancreatic cancer
  • Coeliac disease
  • Zollinger-ellison syndrome 
  • Gastrointestinal or pancreatic surgeries


Dietary Advice 
  • Eat small, frequent meals rather than eating three large meals per day which avoids overloading the pancreas.
  • Limit fat intake
  • Increase protein intake: Consuming protein supplements or protein-rich foods such as lean meat, fish, and poultry may be beneficial
  • Avoid alcohol
  • Consider vitamin and mineral supplements


Pancreatin

Pancreatin contains the three main groups of digestive enzymes: lipase, amylase and protease. These enzymes respectively digest fats, carbohydrates and proteins into their basic components so that they can be absorbed and utilised by the body. 

Treatment- Pancreatin

Dose of pancreatin varies depending on the individual and the severity of the condition being treated







Side effects: abdominal pain, nausea, vomiting, and diarrhoea

Contraindications: Pancreatin should not be used in people with a known hypersensitivity to pork or pork products, as the supplement is derived from pigs

Pancreatin should not be used in people with acute pancreatitis, as the supplement may exacerbate inflammation and damage to the pancreas

Patients may try acid-suppressing drugs (proton pump inhibitors or H2-receptor antagonists) who experience may be trialled in patients who continue to experience acidic symptoms despite high doses of pancreatin (although no evidence)