Potassium
Hyperkalaemia (above 5.0 mmol/L):
- ACE inhibitors (e.g., lisinopril, enalapril)
- Angiotensin receptor blockers (ARBs) (e.g., losartan, valsartan)
- Potassium-sparing diuretics (e.g., spironolactone, triamterene)
- Nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g., ibuprofen, naproxen)
- Heparin
- Cyclosporine
- Tacrolimus
Hypokalaemia (below 3.5mmol/L):
- Loop diuretics (e.g., furosemide, bumetanide)
- Thiazide diuretics (e.g., hydrochlorothiazide, chlorthalidone)
- Corticosteroids (e.g., prednisone, dexamethasone)
- Beta-2 agonists (e.g., albuterol, salmeterol)
- Insulin (high doses)
- Amphotericin B
- Aminoglycoside antibiotics (e.g., gentamicin, tobramycin)
- Theophyllines
sodium
Hyponatraemia (below 133mmol/L)
- Diuretics (e.g., thiazides, loop diuretics)
- Antidepressants (e.g., selective serotonin reuptake inhibitors, tricyclic antidepressants i.e. fluoxetine, sertraline)
- Antipsychotics (e.g., haloperidol, olanzapine)
- Anticonvulsants (e.g., carbamazepine, oxcarbazepine)
- Opioids (e.g., morphine, fentanyl)
- MDMA (ecstasy)
Hypernatremia more than 145mmol/L:
- Lithium
- Diuretics (e.g., thiazides)
- Corticosteroids (e.g., prednisone, dexamethasone)
- Sodium bicarbonate
- Sodium polystyrene sulfonate
- Vasopressin (antidiuretic hormone, ADH)
- Amphetamines
- Anabolic steroids
- Oestrogens
Magnesium
Hypomagnesia (Below 1.8 mg/dL (0.74 mmol/L)
- Proton pump inhibitors (e.g., omeprazole, lansoprazole)
- Loop and thiazide diuretics (e.g., furosemide, hydrochlorothiazide)
- Aminoglycoside antibiotics (e.g., gentamicin, tobramycin)
- Cisplatin
- Cyclosporine
- Tacrolimus
- Pentamidine
Hypermagnesia (Above 2.6 mg/dL (1.07 mmol/L)
- Magnesium-containing antacids
- Magnesium supplements
- Laxatives containing magnesium
- Diuretics that conserve magnesium (e.g., spironolactone)
- Lithium
- ACE inhibitors (e.g., lisinopril, enalapril)
- Angiotensin receptor blockers (ARBs) (e.g., losartan, valsartan)
Calcium
Hypocalcaemia: [Total Serum Calcium: Below 8.5 mg/dL (2.12 mmol/L) or Ionized Calcium: Below 4.5 mg/dL (1.12 mmol/L)]
- Bisphosphonates (e.g., alendronate, risedronate)
- Loop diuretics (e.g., furosemide, bumetanide)
- Glucocorticoids (e.g., prednisone, dexamethasone)
- Phenytoin
- Phenobarbital
- Rifampin
- Aminoglycoside antibiotics (e.g., gentamicin, tobramycin)
Hypercalcaemia: [Total Serum Calcium: Above 10.5 mg/dL (2.62 mmol/L) or Ionized Calcium: Above 5.5 mg/dL (1.37 mmol/L)]
- Thiazide diuretics (e.g., hydrochlorothiazide)
- Lithium
- Vitamin D and its analogs (e.g., calcitriol)
- Calcium supplements
- Antacids containing calcium
- Tamoxifen
- Loop diuretics (when used in high doses)